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【學術報告】芬蘭奧博學術大學Hongbo Zhang(張宏博)學術報告
  審核人:

報告題目:Development of Nanoparticles for Clinical Research 

報 告 人:Hongbo Zhang副教授 

報告時間:2019年6月19日(星期三)下午14:30

報告地點:西館XA208

邀 請 人: 盧婷利教授,尹大川教授

承辦學院:生命學院

聯系電話:17391910270

人物簡介:

說明: A person wearing a suit and tie smiling at the cameraDescription automatically generated

張宏博,芬蘭奧博學術大學副教授,上海交通大學特聘客座教授

張宏博博士2012年12月畢業于赫爾辛基大學制藥系。擁有生物制藥,納米科技,微流體技術,癌癥精準醫療,細胞和分子生物學等方面的交叉科研背景,掌握國際領先水準的相關知識技能。發表SCI論文超過80篇,包括影響因子10分以上的頂級文章23篇。在芬蘭和中國以第一負責人主持15個大型項目,總資金超過2000萬人民幣。作為合作人參與多項大型國際合作項目,總資金超過4億人民幣。在微流體和納米醫學領域,師從美國三院院士,哈佛大學David A. Weitz教授。2016年9月,入職芬蘭埃博學術(?bo Akademi University)大學,擔任助理教授,并建立了納米精致醫療課題組。與哈佛大學合作,在埃博學術大學首次搭建了微流體納米及微米粒子合成平臺及微流體單細胞分析平臺。并被芬蘭圖爾庫生物技術中心聘為課題組組長,與合作者共同組建了Single Cell Omics平臺,該平臺處于世界領先地位,預期將成為專業領域芬蘭第一,歐洲前五的單細胞分析平臺。2018年11月,基于優異的表現,讓埃博學術大學打破了TenureTrack的3年評審規則,提前評審為副教授。張宏博博士注重于產學研結合,目前有多項專利在進行申請,并和淮海融泰控股集團聯合,投資5000萬人民幣,組建了中芬生物科技高新產業孵化基地,兼職執行董事。另外,張宏博博士也積極參加社會活動,擔任芬蘭華人科技協會會長,北歐致公協會副會長,芬蘭市長協會會員,曾多次接待國家省部級領導到芬蘭考察,并為中芬兩國合作做出重大貢獻。2017年及2018年,作為優秀華人,兩次在北京被政協副主席,原科技部部長萬鋼接見。

研究內容簡介:

Introduction/Purpose

Nanotechnology has provided revolutionary impacts for the traditional medication. The nanometer size is highly relevant to many biological conditions, for example 50-200 nm particles tend to accumulate in tumor tissue due to the enhanced permeability and retention (EPR) effect. Moreover, the nanoparticles can be endowed with character of smart, responsive, targeted, multi-functional and etc. However, there are also distinct challenges for nano-medication, including the toxicity, cost, unwanted immune response, industry scale fabrications etc. More research focuses should be taken in the clinical translation of nanomaterials.

Methods

Our research focuses on the development of functional nanomaterials for solving real clinical problems. We have multidisciplinary team from chemistry, material science, engineering, medicine and biology. We always initial the project with clinical doctors and their clinical questions, and the clinical doctors and/or medical students are involved in the projects from start to the end. We synthesize all kinds of nanomaterials, and we are especially interested in mesoporous silica

nanoparticles, the synthetic and nature polymers, DNA nanoparticles and etc. We also apply microfluidic technology for nanoparticles and microparticles fabrication.

Results

Here we present the examples on how we utilized functional materials and microfluidics for different types of applications. Including, targeted cancer drug delivery, cancer immune therapy, image-guided cancer surgery, biosensor for diagnostics, scaffold and hydrogel for wound healing and spinal cord regeneration, and biomimetic scaffold for bone regeneration etc. Moreover, we present how Microfluidics improve the monodisperse, reproducibility and efficiency of the nano-fabrication.

Conclusions

Different types of nanomaterials have shown great potential in diagnostics, imaging, therapy and

especially in consideration of precision nano-medication. Moreover, microfluidics enable the industrial scale fabrication of nanoparticles. We hope very much that you will find hints from those examples on the clinical translational potential.

Selected references

[1] Y. Yan, H. Chen, H. Zhang, C. Guo, K. Yang, K. Chen, R. Cheng, N. Qian, N. Sandler, Y. S. Zhang, Biomaterials 2019, 190, 97.

[2] Z. Liu, Y. Li, W. Li, W. Lian, M. Kemell, S. Hietala, P. Figueiredo, L. Li, E. M?kil?, M. Ma, Materials Horizons 2019.

[3] Y. Zhu, H. Zhang, Y. Zhang, H. Wu, L. Wei, G. Zhou, Y. Zhang, L. Deng, Y. Cheng, M. Li, Adv. Mater. 2018, 1805452.

[4] R. Zhong, Q. Tang, S. Wang, H. Zhang, F. Zhang, M. Xiao, T. Man, X. Qu, L. Li, W. Zhang, Adv. Mater. 2018, 30, 1706887.

[5] Y. Zhang, J. Tu, D. Wang, H. Zhu, S. K. Maity, X. Qu, B. Bogaert, H. Pei, H. Zhang, Adv. Mater. 2018, http://onlinelibrary.wiley.com/doi/10.10.

[6] H. Zhang, Y. Zhu, L. Qu, H. Wu, H. Kong, Z. Yang, D. Chen, E. M?kil?, J. Salonen, H. A. Santos, Nano Lett. 2018, 18, 1448.

[7] Y. Yan, T. Sun, H. Zhang, X. Ji, Y. Sun, X. Zhao, L. Deng, J. Qi, W. Cui, H. A. Santos, Adv. Funct. Mater. 2018, 1807559.

[8] S. Qi, P. Zhang, M. Ma, M. Yao, J. Wu, E. M?kil?, J. Salonen, H. Ruskoaho, Y. Xu, H. A. Santos, Small 2018, 1804332.

[9] X. Mao, R. Cheng, H. Zhang, J. Bae, L. Cheng, L. Zhang, L. Deng, W. Cui, Y. Zhang, H. A. Santos, Advanced Science 2018, 1801555.

[10] Z. Liu, Y. Li, W. Li, C. Xiao, D. Liu, C. Dong, M. Zhang, E. M?kil?, M. Kemell, J. Salonen, Adv. Mater. 2018.

[11] D. Liu, H. Zhang, F. Fontana, J. T. Hirvonen, H. A. Santos, Adv. Drug Deliv. Rev. 2018, 128, 54.

[12] J. Ji, F. Ma, H. Zhang, F. Liu, J. He, W. Li, T. Xie, D. Zhong, T. Zhang, M. Tian, Adv. Funct. Mater. 2018, 1801738.

[13] H. Zhang, D. Liu, M. A. Shahbazi, E. M?kil?, B. Herranz‐Blanco, J. Salonen, J. Hirvonen, H. A. Santos, Adv. Mater. 2014, 26, 4497.

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院系地址:陜西省 西安市 西北工業大學生命學院 郵編:710072

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